(3-bromo-6-methoxy-2-methylphenyl)-(2,3,4-trimethoxy-6-methylphenyl)methanone

C19H21BrO5

409.271

220899-03-6

The original drug is white to off-white crystals with a slight musty smell. Melting point: 99.2-100.8 degree ; Vapor pressure: 1.53×10-4 Pa (20 degree ); Solubility in water (mg/L, 20 degree ): 0.552 (pH5), 0.457 (pH7), 0.457 (pH 9). Solubility in organic solvents (g/L, 20 degree ): acetone 403, acetonitrile 165, dichloromethane 1950.

Metrafenone is classified into the B6 subgroup of the B family in the International Fungicide Resistance Action Committee (FRAC) and has a unique pathogenic actin action site. It can interfere with the formation of appressoria during powdery mildew fungus spore germination, hinder the establishment of polar actin tissue, inhibit the formation of mycelium tip cells and the normal growth and development of mycelium. This effectively inhibits the invasion of powdery mildew and controls the occurrence of diseases. It has obvious preventive and therapeutic effects.

42% metrafenone suspension; representative product: Yingteng

90~180 g/hm2 spray.

1. High activity:

2. Special mechanism of action: Metrafenone has a unique and novel mechanism of action. Unlike general fungicides, which act on the respiratory chain, cell wall, etc., Metrafenone directly acts on the cytoskeleton of the bacteria - actin, causing it to be destroyed and disintegrated. Causes abnormal branching of mycelium and slows down growth, thereby achieving the purpose of preventing and controlling powdery mildew.

3. No cross-resistance: Metrafenone has no cross-resistance with dimethylation inhibitors and anilinopyrimidine fungicides.

4. Special effects on powdery mildew:

5. Good compoundability:

Bixafen+Metrafenone:

Trifloxystrobin + Metrafenone:

Metrafenone + Fluopicolin:

Metalaxyl + Metrafenone:

Metrafenone + Cyanostrobin:

Metrafenone + Ethylpyridinol/ethylpyridinol sulfonate:

Metrafenone + Methoxyacrylates (azoxystrobin, mesostrobin, mesostrobin, tristrobin):

Metrafenone+Carbendazim/thiophanate-methyl/chlorothalonil:

Metrafenone+Metrafenone:

Metrafenone + Triazole fungicides (epoconazole, tetrafluoroconazole, myconazole, myconazole):

Phylconazole + Fludioxonil + Metrafenone:

The core synthesis route: using 2-hydroxy-6-methylbenzoic acid methyl ester as raw material, after bromination, hydrolysis, and chlorination reactions, it is then reacted with 3,4,5-trimethoxytoluene to obtain Metrafenone.